| | Matchday 1 | | |
| | 14 September 2010 Tuesday | | |
| A | Twente - Internazionale | FC Twente Stadion, Enschede (NED) | 2-2 |
| A | Bremen - Tottenham | Weserstadion, Bremen (GER) | 2-2 |
| B | Lyon - Schalke | Stade de Gerland, Lyon (FRA) | 1-0 |
| B | Benfica - H. Tel-Aviv | Estádio do SL Benfica, Lisbon (POR) | 2-0 |
| C | Man. United - Rangers | Old Trafford, Manchester (ENG) | 0-0 |
| C | Bursaspor - Valencia | Atatürk Stadyumu, Bursa (TUR) | 0-4 |
| D | Barcelona - Panathinaikos | Camp Nou, Barcelona (ESP) | 5-1 |
| D | København - Rubin | Parken Stadion, Copenhagen (DEN) | 1-0 |
| | 15 September 2010 Wednesday | | |
| E | Bayern - Roma | Fußball Arena München, Munich (GER) | 2-0 |
| E | CFR Cluj - Basel | Stadionul Dr Constantin Rădulescu, Cluj-Napoca (ROU) | 2-1 |
| F | Marseille - Spartak Moskva | Stade Vélodrome, Marseille (FRA) | 0-1 |
| F | Žilina - Chelsea | Štadión MŠK Žilina, Zilina (SVK) | 1-4 |
| G | Real Madrid - Ajax | Estadio Santiago Bernabéu, Madrid (ESP) | 2-0 |
| G | Milan - Auxerre | Stadio Giuseppe Meazza, Milan (ITA) | 2-0 |
| H | Arsenal - Braga | Arsenal Stadium, London (ENG) | 6-0 |
| H | Shakhtar Donetsk - Partizan | Donbass Arena, Donetsk (UKR) | 1-0 |
| | Matchday 2 | | |
| | 28 September 2010 Tuesday | | |
| E | Basel - Bayern | St. Jakob-Park, Basel (SUI) | 1-2 |
| E | Roma - CFR Cluj | Stadio Olimpico, Rome (ITA) | 2-1 |
| F | Spartak Moskva 18:30 Žilina | Luzhniki Stadion, Moscow (RUS) | 3-0 |
| F | Chelsea - Marseille | Stamford Bridge, London (ENG) | 2-0 |
| G | Auxerre - Real Madrid | Stade Abbé-Deschamps, Auxerre (FRA) | 0-1 |
| G | Ajax - Milan | Amsterdam ArenA, Amsterdam (NED) | 1-1 |
| H | Partizan - Arsenal | Stadion FK Partizan, Belgrade (SRB) | 1-3 |
| H | Braga - Shakhtar Donetsk | Estádio Municipal de Braga, Braga (POR) | 0-3 |
| | 29 September 2010 Wednesday | | |
| A | Tottenham - Twente | White Hart Lane, London (ENG) | 4-1 |
| A | Internazionale - Bremen | Stadio Giuseppe Meazza, Milan (ITA) | 4-0 |
| B | H. Tel-Aviv - Lyon | Bloomfield Stadium, Tel Aviv (ISR) | 1-2 |
| B | Schalke - Benfica | Arena AufSchalke, Gelsenkirchen (GER) | 2-0 |
| C | Valencia - Man. United | Estadi de Mestalla, Valencia (ESP) | 0-1 |
| C | Rangers - Bursaspor | Ibrox Stadium, Glasgow (SCO) | 1-0 |
| D | Rubin - Barcelona | Centralni, Kazan (RUS) | 1-1 |
| D | Panathinaikos - København | OACA Spyro Louis Stadium, Athens (GRE) | 0-2 |
| | Matchday 3 | | |
| | 19 October 2010 Tuesday | | |
| E | Roma - Basel | Stadio Olimpico, Rome (ITA) | 1-3 |
| E | Bayern - CFR Cluj | Fußball Arena München, Munich (GER) | 3-2 |
| F | Spartak Moskva - Chelsea | Luzhniki Stadion, Moscow (RUS) | 0-2 |
| F | Marseille - Žilina | Stade Vélodrome, Marseille (FRA) | 1-0 |
| G | Ajax - Auxerre | Amsterdam ArenA, Amsterdam (NED) | 2-1 |
| G | Real Madrid - Milan | Estadio Santiago Bernabéu, Madrid (ESP) | 2-0 |
| H | Braga - Partizan | Estádio Municipal de Braga, Braga (POR) | 2-0 |
| H | Arsenal - Shakhtar Donetsk | Arsenal Stadium, London (ENG) | 5-1 |
| | 20 October 2010 Wednesday | | |
| A | Internazionale - Tottenham | Stadio Giuseppe Meazza, Milan (ITA) | 4-3 |
| A | Twente - Bremen | FC Twente Stadion, Enschede (NED) | 1-1 |
| B | Schalke - H. Tel-Aviv | Arena AufSchalke, Gelsenkirchen (GER) | 3-1 |
| B | Lyon - Benfica | Stade de Gerland, Lyon (FRA) | 2-0 |
| C | Rangers - Valencia | Ibrox Stadium, Glasgow (SCO) | 1-1 |
| C | Man. United - Bursaspor | Old Trafford, Manchester (ENG) | 1-0 |
| D | Panathinaikos - Rubin | OACA Spyro Louis Stadium, Athens (GRE) | 0-0 |
| D | Barcelona - København | Camp Nou, Barcelona (ESP) | 2-0 |
| | Matchday 4 | | |
| | 2 November 2010 Tuesday | | |
| A | Tottenham - Internazionale | White Hart Lane, London (ENG) | 3-1 |
| A | Bremen - Twente | Weserstadion, Bremen (GER) | 0-2 |
| B | H. Tel-Aviv - Schalke | Bloomfield Stadium, Tel Aviv (ISR) | 0-0 |
| B | Benfica - Lyon | Estádio do SL Benfica, Lisbon (POR) | 4-3 |
| C | Valencia - Rangers | Estadi de Mestalla, Valencia (ESP) | 3-0 |
| C | Bursaspor - Man. United | Atatürk Stadyumu, Bursa (TUR) | 0-3 |
| D | Rubin - Panathinaikos | Centralni, Kazan (RUS) | 0-0 |
| D | København - Barcelona | Parken Stadion, Copenhagen (DEN) | 1-1 |
| | 3 November 2010 Wednesday | | |
| E | Basel - Roma | St. Jakob-Park, Basel (SUI) | 2-3 |
| E | CFR Cluj - Bayern | Stadionul Dr Constantin Rădulescu, Cluj-Napoca (ROU) | 0-4 |
| F | Chelsea - Spartak Moskva | Stamford Bridge, London (ENG) | 4-1 |
| F | Žilina - Marseille | Štadión MŠK Žilina, Zilina (SVK) | 0-7 |
| G | Auxerre - Ajax | Stade Abbé-Deschamps, Auxerre (FRA) | 2-1 |
| G | Milan - Real Madrid | Stadio Giuseppe Meazza, Milan (ITA) | 2-2 |
| H | Partizan - Braga | Stadion FK Partizan, Belgrade (SRB) | 0-1 |
| H | Shakhtar Donetsk - Arsenal | Donbass Arena, Donetsk (UKR) | 2-1 |
| | Matchday 5 | | |
| | 23 November 2010 Tuesday | | |
| E | Roma - Bayern | Stadio Olimpico, Rome (ITA) | |
| E | Basel - CFR Cluj | St. Jakob-Park, Basel (SUI) | |
| F | Spartak Moskva - Marseille | Luzhniki Stadion, Moscow (RUS) | |
| F | Chelsea - Žilina | Stamford Bridge, London (ENG)/td> | |
| G | Ajax - Real Madrid | Amsterdam ArenA, Amsterdam (NED) | |
| G | Auxerre - Milan | Stade Abbé-Deschamps, Auxerre (FRA) | |
| H | Braga - Arsenal | Estádio Municipal de Braga, Braga (POR) | |
| H | Partizan - Shakhtar Donetsk | Stadion FK Partizan, Belgrade (SRB) | |
| | 24 November 2010 Wednesday | | |
| A | Internazionale - Twente | Stadio Giuseppe Meazza, Milan (ITA) | |
| A | Tottenham - Bremen | White Hart Lane, London (ENG) | |
| B | Schalke - Lyon | Arena AufSchalke, Gelsenkirchen (GER) | |
| B | H. Tel-Aviv - Benfica | Bloomfield Stadium, Tel Aviv (ISR) | |
| C | Rangers - Man. United | Ibrox Stadium, Glasgow (SCO) | |
| C | Valencia - Bursaspor | Estadi de Mestalla, Valencia (ESP) | |
| D | Rubin - København | Centralni, Kazan (RUS) | |
| D | Panathinaikos - Barcelona | OACA Spyro Louis Stadium, Athens (GRE) | |
| | Matchday 6 | | |
| | 7 December 2010 Tuesday | | |
| A | Twente - Tottenham | FC Twente Stadion, Enschede (NED) | |
| A | Bremen - Internazionale | Weserstadion, Bremen (GER) | |
| B | Lyon - H. Tel-Aviv | Stade de Gerland, Lyon (FRA) | |
| B | Benfica - Schalke | Estádio do SL Benfica, Lisbon (POR) | |
| C | Man. United - Valencia | Old Trafford, Manchester (ENG) | |
| C | Bursaspor - Rangers | Atatürk Stadyumu, Bursa (TUR) | |
| D | Barcelona - Rubin | Camp Nou, Barcelona (ESP) | |
| D | København - Panathinaikos | Parken Stadion, Copenhagen (DEN) | |
| | 8 December 2010 Wednesday | | |
| E | Bayern - Basel | Fußball Arena München, Munich (GER) | |
| E | CFR Cluj - Roma | Stadionul Dr Constantin Rădulescu, Cluj-Napoca (ROU) | |
| F | Marseille - Chelsea | Stade Vélodrome, Marseille (FRA) | |
| F | Žilina - Spartak Moskva | Štadión MŠK Žilina, Zilina (SVK) | |
| G | Real Madrid - Auxerre | Estadio Santiago Bernabéu, Madrid (ESP) | |
| G | Milan - Ajax | Stadio Giuseppe Meazza, Milan (ITA) | |
| H | Arsenal - Partizan | Arsenal Stadium, London (ENG) | |
| H | Shakhtar Donetsk - Braga | Donbass Arena, Donetsk (UKR) | |
